CANDLE syndrome, also known as proteasome associated autoinflammatory syndrome (PRAAS), is an autosomal recessive interferonopathy caused by mutations in the PSMB8 (Proteasome 20S Subunit Beta 8) gene, which encodes the β5i subunit of the immunoproteasome. The gene discussed is PSMB8; the disease is proteosome-associated autoinflammatory syndrome.