While increased predicted expression was associated with cataract risk for 79 of the Bonferroni-significant gene-tissue pairs (e.g., IGHMBP2-colon sigmoid, z = 8.25), decreased predicted expression was associated with cataract for 123 Bonferroni-significant gene-tissue pairs (e.g., MRPL21 - whole blood, z = -7.64) (Figures 1, 2). The gene discussed is IGHMBP2; the disease is cataract.