developed two AI models, based on either tomographic changes or clinical risk factors, to identify risk factors underlying keratoconus progression and label patients with either likely disease “progression” or “no progression.” (129) They found that elevated serum immunoglobin E (IgE), systemic allergies, eye rubbing, and serum vitamin D level were important characteristics in the evaluation for the risk of keratoconus progression (129). The gene discussed is IGHE; the disease is keratoconus.