Although cytokine recruitment is mainly to areas of infection and surrounding cells (in this case, the lungs and airway passages), SARS-CoV-2 infection also causes systemic hypercoagulability activated by IL-1 and IL-6, which increases hepatocyte production of fibrinogen, PAI-1, and CRP, thereby increasing systemic inflammation and circulation of clotting and antifibrinolytic factors (Figure 3). Here, SERPINE1 is linked to infection.