The frequency distribution analysis of the BER genes (XRCC1, XRCC2, XRCC3) in conjunction with rs1042522, rs28934571 SNPs of the tumor suppressor TP53 gene confirmed notable findings with significant association of homozygous variant (A/A) genotype of XRCC1 (Arg399Gln) (OR=4.28; 95% CI: 1.81-10.80; p=0.0009) while the variant (T/T) genotype of XRCC3 (Thr241Met) demonstrated negative association with GI cancer risk (OR=0.32; 95% CI: 0.11-0.91; p=0.032) within the studied population. Here, XRCC3 is linked to neoplasm.