For example, c-kit (CD117) or DOG1 is present in GISTs; desmin in leiomyomas; S-100 in schwannomas; smooth muscle actin in glomus tumors; anaplastic lymphoma kinase in inflammatory myofibroblastic tumors; and chromogranin A and synaptophysin in carcinoids [11,12]. This evidence concerns the gene DES and leiomyoma.