In addition to recurrent skin abscesses, types of pneumonia with pneumatocele formation, and elevated serum IgE levels, this syndrome can also manifest with other symptoms such as dental issues such as misaligned or missing teeth, bone abnormalities such as joint hyperextensibility or spinal curvature, facial anomalies such as a broad forehead, large eyes, and prominent jaw, recurrent upper respiratory tract infections, and various cutaneous complications. The gene discussed is IGHE; the disease is Recurrent upper respiratory tract infections.