CD4 and chordoma: Dancsok detected and calculated the number of infiltrating immune cells per unit area in 28 chordoma cases, they found that macrophages were the highest density infiltrating cell population, with CD163+ M2 macrophages far more than CD86+ M1 macrophages, but both of them were much more than TILs, which differed from the presence of large CD4+ T cell infiltrated in chordomas mentioned in other studies (21).