As for IL-6 and IL-8, studies have shown that the expression levels of IL-6 and IL-8 in the serum of patients with chordoma are significantly higher than those of normal people (38), and their secretion levels in chordoma cells are significantly increased after co-culture with macrophages in vitro (35), indicating that their secretion was affected by tumor-immune cell interactions, but the mechanism was still unclear. This evidence concerns the gene CXCL8 and neoplasm.