CD4 and neoplasm: also found that there was a significant positive correlation between CD3+ T lymphocyte infiltration and the degree of tumor invasion, overall survival (OS) and local relapse-free survival (LRFS) in 54 spinal chordomas, and the density of CD4+ T lymphocytes was significantly associated with OS and LRFS, while the density of Foxp3+ regulatory T cells and CD8+ T cells was associated with OS (23, 24).