NDRG1 and hepatocellular carcinoma: Paradoxically, another study demonstrated that NDRG1 phosphorylation at Thr346 in hepatocellular carcinoma cells promotes its pro-oncogenic role and showed that phosphorylated NDRG1 (p-NDRG1) at Ser330 mainly localizes in the nucleus, while p-NDRG1 at Thr346 is predominantly found in the cytoplasm (Park et al., 2018).