Using LPS-induced depressed mice, after gavage administration of Chiisanoside (5.0 mg/kg/d), it effectively reduced serum IL-6 and TNF-α levels, as well as improved oxidative stress-related indices, and significantly increased immobility time of TST and FST, suggesting that Chiisanoside may improve depression by modulating the levels of inflammatory factors. Here, TNF is linked to depressive symptom measurement.