Using LPS-induced depressed mice, after gavage administration of Chiisanoside (5.0 mg/kg/d), it effectively reduced serum IL-6 and TNF-α levels, as well as improved oxidative stress-related indices, and significantly increased immobility time of TST and FST, suggesting that Chiisanoside may improve depression by modulating the levels of inflammatory factors. The gene discussed is TNF; the disease is major depressive disorder.