TP53 and bladder transitional cell carcinoma: Figure 2D demonstrates CNV alterations of the PRGs on the chromosome. Moreover, the somatic mutation of these DEGs in the TCGA-BLCA cohort was also described. It was revealed that TP53 had the highest mutation frequency (49%); however, the mutation frequencies of other DEGs were all <3% (Figure 2E). The correlation network between PRGs is shown in Figure 2F.