SPINK1 and neoplasm: Furthermore, the expression levels of these features genes of C1 (CXCL9/CXCL10) and C2 (SPINK1/DHES9) in tumor tissues were validated and one C1 (sample A, CXCL9/CXCL10 high + SPINK1/DHES9 low) and one C2 (sample B, SPINK1/DHES9 high + CXCL9/CXCL10 low) sample were screened for subsequent immunofluorescence assay (Figure 4E).