Eight of these pathways, pertinent to the tumor microenvironment, including the Nkt Pathway, Chemokine Receptors Bind Chemokines, Interleukin 2 Family Signaling, Toll-Like Receptor Cascades, Interferon Signaling, Cancer Immunotherapy by PD1 Blockade, Cancer Immunotherapy by CTLA4 Blockade, and Amb2 Neutrophils Pathway, exhibited significant enrichment in the high FAM20A expression group, as indicated by NES, FDR, and p-values (Figures 9B-I). This evidence concerns the gene CTLA4 and cancer.