In our study, we revealed the upregulation of cflar, also called c-flip (CASP8 and FADD-like apoptosis regulator), and tnfrsf1a (tumor necrosis factor receptor superfamily member 1A-like) together with gadd45a in sexual gibel carp after D. pseudospathaceum infection, likely indicating the potential of sexuals to establish an immune reaction to parasite-induced stress, and/or, alternatively, the insufficient capacity of gynogenetic fish to establish an appropriate cell response to trematode infection. Here, CASP8 is linked to Trematode Infections.