Further colocalization analysis identified 9 proteins that may have significant roles in RA disease progression (PP.H4 > 0.7), including FCRL3, IL1RN, CCN4, NMB, MAPK3, HAPLN4, CILP2, ICOSLG, and TMEM9 (Figure 6). The gene discussed is HAPLN4; the disease is rheumatoid arthritis.