Another study showed that serum exosomal membrane type 1 matrix metalloproteinase (MT1-MMP) mRNA was significantly upregulated in patients with gastric cancer compared with healthy controls and patients with chronic gastritis or atypical hyperplasia, with an AUC value of 0.788, sensitivity of 63.9% and specificity of 87.1%, compared with an AUC value of only 0.655 for serum CEA. Here, MMP14 is linked to chronic gastritis.