identified members of the membrane-linked protein family (Annexin A1, A2, A3, A5, A6, A11), nitrogen permease regulator 2-like protein (NPRL2), carcinoembryonic antigen-associated cell adhesion molecule 1 (CEACAM1), mucin 1 (MUC1), in salivary exosomes from lung cancer patients by proteomic analysis, in addition to Prominin-1 (PROM1), histone H4 (HIST1H4A) and tumor necrosis factor alpha-inducible protein 3 (TNFAIP3), which have been identified as biomarkers associated with lung cancer (157). This evidence concerns the gene NPRL2 and lung cancer.