IL18 and inflammation: In conclusion, our data from the present study showed that anti-mIL-1R7, an antibody against mIL-1R7 (the co-receptor of IL-18), significantly inhibited IL-12/IL-18- or LPS- stimulated IFNγ production in mouse spleen cells and peritoneal cells, protected mice from P. acnes/LPS- induced liver injury and systemic inflammation, and prevented mice from LPS-induced acute lung injury and inflammation.