Eight pathways in the Control-vs-IPAA condition had a close relationship to the autoimmune disorders including cushing syndrome, breast cancer, endocrine resistance, AGE-RAGE signaling pathway in diabetic complications, endometrial cancer, basal cell carcinoma, prostate cancer, and MicroRNAs in cancer. This evidence concerns the gene RENBP and Cushing syndrome due to macronodular adrenal hyperplasia.