Similarly, KD of HDAC1 via intravenous injection of adeno-associated virus (AAV)-siRNA carrying cardiomyocyte-specific cTNT (cardiac troponin T) promotor improved cardiac function, restored lipid contents, and reduced myocardial injury as well as inflammation in a coronary heart disease model of rats (Zhou et al., 2022). The gene discussed is HDAC1; the disease is coronary artery disorder.