Cardiac OE of HDAC4-NT (N-terminus) by intravenous injection of AAV9 with the cytomegalovirus (CMV)-enhanced myosin light chain promoter (Myl2) protected against the heart failure on TAC (Lehmann et al., 2018), suggesting that HDAC4-NT can promote cardiac function. The gene discussed is HDAC4; the disease is heart failure.