HDAC2, 3, and 4 are involved in hypertrophic signaling in the heart, as shown by the common phenotype of cardiac hypertrophy in response to cardiomyocyte-specific OE of HDAC2, 3 or 4 (Trivedi et al., 2007; Trivedi et al., 2008; Eom et al., 2011; Zhang L. et al., 2018). Here, HDAC2 is linked to cardiac hypertrophy.