Endothelial-specific KO of HDAC9 with Cdh5-Cre showed reduced plaque area and plaque lipid content, and increased fibrous cap thickness in an atherosclerosis model, suggesting that targeting HDAC9 may aid in the treatment of atherosclerosis (Lecce et al., 2021) (Table 3). The gene discussed is CDH5; the disease is atherosclerosis.