PTGS2 and arthritic joint disease: Celecoxib (CXB) is a selective COX-2 inhibitor NSAID that is used to treat different types of arthritis (e.g., osteoarthritis, rheumatoid arthritis, and juvenile rheumatoid arthritis), acute pain, ankylosing spondylitis, painful menstruation, and colorectal adenomas (Abdellatif et al., 2022).