Rothenberg et al. (2011) showed that eosinophil recruitment and chemokine production critically depend on IL-13Rα1 (receptor for IL-13 induction) and IL-13 signaling after Aspergillus sensitization.In the present study, the challenge posed by A. fumigatus conidia in A549 cells regulated the expression of IL-13, showing that the importance of this cytokine in inducing allergic reactions and that only higher doses of S. boulardii CW could downregulate its expression. This evidence concerns the gene IL13 and allergic disease.