Depending on the stage of infection, bacterial manipulation of the PI3K pathway results in different outcomes that range from facilitating bacterial uptake into the host cells to inhibiting phagosome maturation and lysosomal fusion (Gillooly et al., 2001; Vergne et al., 2003; Vergne et al., 2004; Vergne et al., 2005; Cano et al., 2015). This evidence concerns the gene PIK3CD and infection.