TLR3 and age-related macular degeneration: A meta-analysis of the association between TLR3-rs3775291 polymorphism and AMD risk showed that the T allele of the TLR3-rs3775291 polymorphism was associated with a reduced risk of GA (p = 0.04, OR = 0.78, 95% CI: 0.62-0.98) (137).