There was a significant difference in the CC genotype of TLR4-rs1927914 between AMD patients and healthy controls with the CC genotype and allele appearing to be protective AMD (P = 0.010 OR= 0.358, 95% CI=0.162–0.791), (P = 0.039, OR = 0.698, CI = 0.497-0.983) (25). The gene discussed is TLR4; the disease is age-related macular degeneration.