TLR7 and age-related macular degeneration: The first cohort, based in Dallas, USA, consisted of 396 patients suffering from AMD against 181 controls; 10 polymorphisms across TLRs 1,3-7,10 were identified, however, only the TLR3 polymorphism (rs3775291 L412F, P = 0.01) and TLR7 polymorphism (rs12663316 Xp22.3, P = 0.02) were associated with AMD (130), these were found to not be significant after correction for multiple testing was applied (130).