TLR4 and age-related macular degeneration: In a cohort of 114 AMD patients and 448 healthy control subjects, no significant association between the risk of AMD and the TLR4- rs3775291 polymorphism was found (genotypic OR = 1.55, CI = 0.77-1.67, genotypic P = 0.149, allelic OR = 1.22, CI 0.896-1.67, allelic P = 0.233) (96).