Multiple cells of innate and adaptive immune system exert important functions in BD, including CD4+T cells (76, 77), CD8+ T cells (78), dendritic cells (79), macrophages (80), NK cells (81), neutrophils (82) and B cells (83, 84), and almost all of them could express IL-10 (85). The gene discussed is IL10; the disease is Behcet disease.