Genetic ablation of IL18R1 or blockade of IL-18 receptor signaling could protect mice from autoimmune disease (98, 101).Three SNPs (rs12999364, rs12987977, and rs4851569) located in the IL1RL1–IL18R1 region were associated with ocular manifestations in Chinese BD patients. This evidence concerns the gene IL1RL1 and Behcet disease.