Several studies, including a Sicilian case–control study, a Japanese case–control study, a family-based and a candidate gene study of Canadian patients with MS, and an American nested case–control study, did not discover any connection between VDBP phenotypes and the occurrence of MS.86, 87, 88, 89, 90 Hence, the presence of disease, disease natural history, or the age of onset is not significantly affected by VDBP single nucleotide polymorphisms. Here, GC is linked to myeloid sarcoma.