By summarizing the latest research findings on the structure, polymorphisms, and distribution of VDBP, this review offers valuable insights into the potential involvement of VDBP in various psychiatric disorders such as depressive disorder and schizophrenia, as well as several neurological disorders such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), epilepsy, restless legs syndrome (RLS), and migraine. Here, GC is linked to multiple sclerosis.