GSTM1 and colorectal carcinoma: As a tool for triaging patients, this model could avoid or delay approximately one-third of colonoscopies, with a rate of 5.8% CRC missed in the whole cohort, which is considerably lower than the previously reported 9.12% when a FIT cut-off of 10 μg Hb/g faeces is applied in symptomatic patients (31).