Amadio et al. (Amadio et al., 2017) investigated the relationship between depression and VTE at a molecular level and found that it may be related to the presence of SNP variants on the gene encoding brain-derived neurotrophic factor, which increases susceptibility to depression while leading to concomitant hypercoagulability and platelet hyperreactivity in individuals. This evidence concerns the gene BDNF and thrombophilia.