STAT3 and neoplasm: Dysfunction of tumor-induced DC in NSCLC may be caused by the inhibition of nuclear factor-kappa B (NF-kB) and signal transducer and activator of transcription 3 (STAT3) signaling pathways, leading to downregulation of downstream genes associated with cytokine and chemokine production, as well as antigen presentation (Li et al., 2017).