FOXP3 and cancer: In contrast, in the context of cancer, a distinctive subset known as Vδ2 Tregs, which are specific types of γδ T cells with regulatory activities and Foxp3 expression, can be induced in the presence of antigen stimulation (IPP/IL-2) and TGF-β1 and IL-15 cytokines in vitro (Casetti et al., 2009).