Similarly, IL-1B, mostly secreted from tumor-associated macrophages as a pro-inflammatory cytokine, enhances the expression of ELF3 in LUADs with EGFR mutations, leading to the activation of the PI3K/Akt/NF-κB pathway and consequently contributes to tumor progression (He et al., 2021). The gene discussed is IL1B; the disease is neoplasm.