ICAM1 and neoplasm: Studies have also shown that DNA methyltransferase inhibitors can enhance the antitumor effects of MHC-unrestricted γδ T cell therapy by increasing the expression of adhesion molecules such as intercellular adhesion molecule 1 (ICAM-1) or facilitating immune cytoskeleton reorganization and immune synapse formation, finally improving the tumor-killing efficacy of γδ T cells.