To elucidate the potential association between lipid homeostasis and lung cancer metastasis, the levels of IFN-γ and granzyme B produced by lung NK cells in tumor-bearing Fabp5−/− mice were significantly decreased compared with their wild-type counterparts, suggesting a role for FABP5 in regulating the cytotoxicity of NK cells. This evidence concerns the gene FABP5 and neoplasm.