IL12RB2 and neoplasm: Research has also demonstrated an association between high mutational load and the overexpression of immune-related genes, such as interleukin-12 receptor subunit beta-2 (IL12RB2) and IFN-γ, which are related to Th1 anti-tumor reponse and IL-21, IL-23A, and interleukin 17 receptor A (IL17RA), which play roles in Th17-related pathways (Ye et al., 2013; Chae et al., 2018).