In a recent study by Li et al., the overexpression of wild-type EPHA5 suppressed tumor invasion and migration, in contrast to the effects observed with mutant EPHA5. Further analysis demonstrated that overexpression of wild-type EPHA5 significantly promoted NK cell proliferation and cytotoxicity against NSCLC cells and was associated with decreased cell apoptosis. Here, EPHA5 is linked to neoplasm.