TIMP3 and lung cancer: Conversely, IL-32γ may suppress lung tumor progression by increasing tissue inhibitor of metalloproteinase 3 (TIMP-3) expression, which acts as a tumor suppressor gene (Yun et al., 2018), or by downregulating integrin alpha V (ITGAV)-mediated STAT5 signaling pathways, leading to the suppression of the growth of CD133+ lung cancer stem cells (Lee et al., 2019b).