IRAK1 and uveitis: In the spleen the TLRs signaling molecules IRAK1 and TRAF6 were upregulated in both microRNA146a, and scrambled RNA treated mice whereas in the retina these molecules were downregulated with microRNA 146a delivery and not with scrambled RNA (Figure 8). The results indicate that the most likely mechanism of abrogation of uveitis with local delivery of microRNA146a could be due to suppression of local innate immune response that could translate into suppression of Th1/Th2/Th17 immune response in EAU.