For example, in five loci (CDKN2B-AS1, TMCO1, CAV1/CAV2, chromosome 8q22, SIX1/SIX6) that were previously identified to be associated with POAG in Caucasian populations on a genome-wide scale, only select single nucleotide polymorphisms (SNPs) in the CDKN2B-AS1 and SIX1/SIX6 loci were found to be associated with African American POAG samples (9). Here, SIX1 is linked to open-angle glaucoma.