PLIN5 and Insulin resistance: Additional genes like Plin5 (Perilipin 5), facilitate triglyceride storage and suppress insulin resistance (42), and Crat (Carnitine acetyltransferase) transports fatty acids for β-oxidation across the mitochondrial membranes (43), showed elevated expression, emphasizing that the vascularized adipose spheroids had a higher induction of metabolic genes.