Physiologically, FT3 is a biologically active form of thyroid hormone that, by binding to TRβ in hepatocytes (44), reduces intrahepatic triglyceride and cholesterol content (45), as well as inflammation and oxidative stress, and restores mitochondrial function in hepatocytes (46), to prevent the onset and progression of liver fibrosis. The gene discussed is THRB; the disease is Hepatic fibrosis.