By comparing control Dahl salt-sensitive rats (SS-WT rats) with mutant PON1 knockout rats (SS-PON1 KO rats), maintained both on high salts diets for five weeks to induce hypertensive renal disease, it was observed that SS-PON1 KO rats developed compensated left ventricular hypertrophy after only 4 weeks on high salts diet. This evidence concerns the gene PON1 and hypertensive nephropathy.