Furthermore, it has been proved that HDL from HD and PD patients shifted toward a more proinflammatory phenotype, with remarkable alterations in the lipid moiety (lower levels of cholesteryl ester and phospholipids, and higher levels of triglycerides) and in the protein composition (lower amounts of Apo A-I, Apo AII and paraoxonase 1) [64]. Here, PON1 is linked to Huntington disease.