PLCG1 and cancer: PLCG regulates multiple cellular processes via calcium (Ca2+) mobilization and activation of protein kinase C, other kinases and ion channels, and PLCG is frequently enriched and mutated in various cancers, and is involved in the processes of tumorigenesis, including proliferation, migration, and invasion [32].The expression levels of PLCG signaling marker genes PLCG1 in the HLX22 and HLX02 combination-treated cells decreased, suggesting that HLX22 in combination with HLX02 inhibited PLCG signaling to restrain tumor proliferation, migration, and invasion (Fig. 6b).