ERBB2 and gastric cancer: To investigate the modulatory effect of HLX22 in combination with HLX02 on gene expression profile in gastric cancer cell line with 3 + HER2 expression, we treated NCI-N87 cells with HLX22, HLX02, HLX11, HLX22 in combination with HLX02, or HLX02 in combination with HLX11 for 72 h and then examined the whole transcriptome by RNA-sequencing.