Therefore, HLX02 and HLX11 combination disrupted HER2/EGFR heterodimer formation, and consequently, HLX02 and HLX11 combination only promoted HER2 internalization but could not promote EGFR internalization together in gastric cancer cell lines; EGFR still transduced signals that promoted tumor growth (Fig. 2h). The gene discussed is ERBB2; the disease is neoplasm.