ERBB2 and neoplasm: Our findings indicated that HLX02 and HLX11 combination disrupted HER2/EGFR heterodimer formation, and consequently, HLX02 and HLX11 combination only induced HER2/HER2 homodimers internalization, but could not promote HER2/EGFR heterodimers internalization on gastric cancer cells, and therefore EGFR kept transducing signals that promoted tumor growth (Fig. 2e, h).