By immunohistochemical assay, EAML is positive for melanocytic markers such as HMB‐45, melana protein and melanoma antigen recognized by T cells 1 (MART‐1), tyrosinase, and microphthalmia transcription factor but negative for epithelial markers and S‐100 protein [17, 18, 19, 20]. This evidence concerns the gene PMEL and melanoma.