Reactome enrichment analysis identified Protein kinase RNA- like endoplasmic reticulum kinase (PERK) signaling, diacylglycerol (DAG), and Inositol trisphosphate (IP3) signaling, KIT mediated signaling pathways as the important downregulated pathways in HRAS mutant cancer cells when they are treated with BAY 11-7082, (Fig. 6), which may contribute to tumor growth inhibition of HRAS mutant melanoma cells as observed in Figs. 1, 2 and 3 of our result section. This evidence concerns the gene EIF2AK3 and cancer.