Chemokines and cytokines, such as IFN-γ [39], CXCL9 [40], and CCL20 [41], are related to the recruitment of CD4+ and CD8+ T cells, so the lack of chemokines and cytokines may lead to impaired recruitment of immune cells, thereby causing an immunosuppressive tumor microenvironment. The gene discussed is IFNG; the disease is neoplasm.