Interestingly, no significant difference for IFN‐γ + (Th1), IL‐4+ (Th2), IL‐17A+ (Th17) CD4+ T cells and CD8+ T cells in the mesenteric lymph nodes (MLNs) or lamina propria mononuclear cells (LPMCs) was found between these two groups (Supplementary Figure 3C,D), suggesting the critical role of GSDMB principally in innate immunity during acute colitis. The gene discussed is IFNG; the disease is colitis.