6-Shogaol stimulates ROS production via NOX4 in ovarian cancer, leading to ER stress, eIF2α phosphorylation, and upregulation of activating transcription factor 4 and C/EBP homologous protein (CHOP), which induces apoptosis and overcomes gefitinib resistance [108]. The gene discussed is DDIT3; the disease is ovarian carcinoma.