EGFR and non-small cell lung carcinoma: In EGFRT790M TKI-resistant NSCLC cells, sanguinarine activates NOX3, leading to the accumulation of ROS, resulting in NADPH depletion, causing methionine reductase A (MsrA) to destroy its protein reduction protection against methionine 790 of EGFR, causing EGFR peroxidation and degradation, and inducing cancer cell apoptosis [109].