However, melatonin-induced neutrophils exhibit unique immunological characteristics, such as being recruited to the tumor microenvironment predominantly by tumor cell-released CXCL2, rather than by chemokines secreted by macrophages, to induce reactive oxygen species (ROS)-dependent formation of neutrophil extracellular traps (NETs) that kill tumor cells. Here, CXCL2 is linked to neoplasm.