BHLHE40 and neoplasm: Tumor-associated neutrophils (TANs) were divided into five groups based on their marker genes (Table 2): PMN (circulating neutrophils), TAN-3 (cells transitioning from the periphery to the tumor), TAN-0 (functionally unspecified), TAN-4 (preferentially express interferon-stimulated genes), TAN-2 (inflammatory), and TAN-1 (terminally differentiated with protumor functions, highly glycolytic, and regulated by the BHLHE40 transcription factor).