PFKP and head and neck squamous cell carcinoma: Therefore, this current study aims to assess and validate the expression patterns of PFKP and c-Myc in HNSCC tumors versus adjacent normal tissues, to explore their impact on the clinical features of HNSCC, and to identify the functional roles and the underlying mechanism of a positive feedback loop between PFKP and c-Myc in progression of HNSCC.