To refine the selection of candidate TFs, we analyzed the correlation of mRNA levels of these TFs with PFKP using the TCGA-HNSCC data and found that two TFs (c-Myc and CTCF) exhibited a positive correlation with PFKP (r > 0.3, P < 0.05; Fig. 7B and Supplementary Fig. 6A). The gene discussed is MYC; the disease is head and neck squamous cell carcinoma.