Fisher’s exact test was used for Gender, Glaucoma, Glaucoma after shunt, Hypertension, T2DM, Aβ positive brain biopsy and HPτ positive brain biopsy; Pearson Chi-Square was used for Glaucoma type and Independent Samples T-test was used for age; POAG, primary open angle glaucoma; PEXG pseudoexfoliative glaucoma; NTG, normal tension glaucoma; PACG, primary angle-closure glaucoma; NPH, normal pressure hydrocephalus; T2DM, type 2 diabetes; Aβ, Amyloid-β; HPτ, hyperphosphorylated tau. Here, MRS2 is linked to open-angle glaucoma.