Together with our findings of down-regulated RNF43 and ZNRF3 in BRAF-mutated PM-CRC (Figs. 3C, 4E and F, [32]) and enrichment of BRAF and RNF43 mutations in right sided primary CRC cases (Fig. 2C, supplementary file 7), previous findings that the BRAF-mutated PM-CRC are associated with right-sided serrated primary CRC are confirmed. Here, BRAF is linked to colorectal carcinoma.