CTSE and colorectal carcinoma: Among the top up-regulated genes in BRAF mutated compared to WT cases were ANXA10 (Annexin A10), TFF1 (Trefoil factor 1), TFF2 (Trefoil factor 2) and CTSE (Cathepsin E), which are all markers associated with BRAF mutated right sided sessile serrated primary CRC [27–30].