Finally, ROC analysis based on clinical factors and a combination of two laboratory parameters was performed, and a statistically significant model was reached when clinical factors (DM and AF) were combined with laboratory parameters such as lymphocyte count and IL-6, yielding a sensitivity of 64%, a specificity of 87.9% and an area under the curve (AUC) of 0.818, as shown in Model 7 in Fig. 1. This evidence concerns the gene IL6 and atrial fibrillation.