Studies have shown that during the degradation of UA, intracellular oxygen free radicals are generated, The increase of fibroblast growth factor-23 (FGF-23), decrease of calcitriol, increase of parathyroid hormone, increase of phosphate, associated bone disease, and vascular calcification are the main biochemical characteristics of mineral metabolism changes [20], the up-regulation of FGF-23 is one of the pathogenesis mechanisms of CKD-MBD [21, 22]. This evidence concerns the gene PTH and Marchiafava-Bignami disease.