GLA and Fabry disease: Fabry disease (FD) is an X-linked lysosomal storage disorder of glycosphingolipid metabolism caused by rare inborn mutations in the GLA gene encoding α-galactosidase A, which causes progressive accumulation of globotriaosylceramide (GL-3 or Gb3) and its deacylated forms, globotriaosylsphingosine (lyso-GL-3 or lyso-Gb3) substrates in lysosomes [1, 2].