Mechanistically, downregulation of miR‐94444 and miR‐12745 promotes high SPP1 expression, fostering cancer progression via direct pathway induction and interaction with growth factor receptor pathways, activating genes conducive to cancer advancement.CD44, a non‐kinase transmembrane glycoprotein, acts as a receptor for SPP1 in this study.46 This evidence concerns the gene CD44 and cancer.