The results showed that the overexpression of GPC-1 promoted the proliferation of HCC cell lines and inhibited its apoptosis, accompanied by the upregulation of Bcl-2 expression and the downregulation of Bax expression, while knockdown of GPC-1 inhibited proliferation, promoted apoptosis, and changed the expression of Bcl-2 and Bax in 97H and HUH7. The gene discussed is BCL2; the disease is hepatocellular carcinoma.