While NRF2 expression levels were similar between normal salivary gland tissues and AdCC tumors from each anatomic subsite, analysis of the canonical targets NQO1, TXNRD1, and HMOX1 which are directly regulated by NRF2 revealed that parotid gland AdCCs have elevated levels of the expression (Fig. 3A). The gene discussed is HMOX1; the disease is adrenocortical carcinoma, hereditary.