Similarly, while individual deletion of METTL2 or METTL6 had a modest effect on growth of MCF7 human breast cancer cells, the further siRNA-mediated depletion of either METTL6 in the METTL2 KO cells, or knockdown of METTL2 in the METTL6 KO cells strongly suppressed cell proliferation (Supplementary Fig. 5a–c). Here, METTL2B is linked to breast carcinoma.