P2RX7 and neoplasm: For IFNAR1 KO MC38 tumors, while single CV-1 treatment had no therapeutic effect, additional injection of BzATP, a P2X7 receptor agonist54, significantly inhibited tumor growth, further suggesting that ATP is an important factor downstream of tumor cell-intrinsic IFN-I signaling-mediated antitumor effect (Fig. 2h).